anti-alpha-1 Microglobulin, mAb (10A12)

Product description: Monoclonal Antibody. Recognizes the Human protein. Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. alpha1-microglobulin (protein HC) is a lipocalin with immunosuppressive properties. The lipocalins are a family of proteins which transport small hydrophobic molecules such as steroids, bilins, retinoids, and lipids. Well known lipocalins are alpha1-microglobulin, alpha-1-acid glycoprotein (orosomucoid), apolipoprotein D, beta-lactoglobulin, and complement component C8 gamma chain etc. A gene in the lipocalin cluster encodes alpha1-microglobulin together with a Kunitz-type proteinase inhibitor, bikunin. The gene is translated into the alpha1-microglobulin-bikunin precursor, which is subsequently cleaved and the two proteins secreted to the blood separately. alpha1-microglobulin, is a monomeric protein of a molecular size of 27 kDa. It is produced by the liver and circulates in a free form, but is also bound in complexes to high molecular weight molecules. In human plasma, approx. 50% of alpha1-microglobulin forms a one-to-one complex with monomeric immunoglobulin A (IgA) by a reduction resistant bond. Normal urine contains very small amounts of alpha1-microglobulin. In conditions with disturbed tubular function, reabsorption of alpha1-microglobulin is reduced and increased amounts are found in urine. Urinary alpha1-microglobulin seems a promising marker for renal abnormalities and for the differentiation of various nephrological and urological pathologies. Inter-alpha-trypsin inhibitor inhibits trypsin, plasmin, and lysosomal granulocytic elastase. Inhibits calcium oxalate crystallization.

Alternate Names/Synonyms: HCP; AMBP; Protein HC; alpha-1 Microglycoprotein; Complex-forming Glycoprotein Heterogeneous in Charge

Product Type: Monoclonal Antibody

Clone: 10A12

Isotype: Mouse IgG1 kappa

Immunogen: Protein purified from human plasma.

Applications: ELISA, WB

Species Crossreactivity: Human

Formulation: Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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Literature References: 1) Penders J and Delanghe JR, (2004) Clin Chim Acta. 346(2):107-118. (General)2) Bo Akerstrom et al. (2000) Biochim Biophys Acta. 1482(1-2):172-184. (General)3) Xu S and Venge P, (2000) Biochim Biophys Acta. 1482(1-2):298-307. (General)