anti-Peroxiredoxin 6, pAb

Product description: Polyclonal Antibody. Recognizes the Human, Mouse, Rat protein. Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. Peroxiredoxin (Prx) is a growing peroxidase family, whose mammalian members have been known to connect with cell proliferation, differentiation, and apoptosis. Many isoforms (about 50 proteins), collected in accordance to the amino acid sequence homology, particularly amino-terminal region containing active site cysteine residue, and the thiol-specific antioxidant activity, distribute throughout all the kingdoms. Among them, mammalian Prx consists of 6 different members grouped into typical 2-Cys, atypical 2-Cys Prx, and 1-Cys Prx. Except Prx 6 belonging to 1-Cys Prx subgroup, the other five 2-Cys Prx isotypes have the thioredoxin-dependent peroxidase (TPx) activity utilizing thioredoxin, thioredoxin reductase, and NADPH as a reducing system. Mammalian Prxs are 20 - 30 kilodalton in molecular size and vary in subcellular localization: Prx 1, 2, and 6 in cytosol, Prx 3 in mitochondria, Prx 4 in ER and secretion, Prx 5 showing complicated distribution including peroxisome, mitochondria and cytosol. Involved in redox regulation of the cell. Can reduce H2O2 and short chain organic, fatty acid, and phospholipid hydroperoxides. May play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury.

Alternate Names/Synonyms: AOP2; NSGPx; PRDX6; aiPLA2; 1-Cys PRX; EC=3.1.1.-; EC=1.11.1.9; EC=1.11.1.15; 24 kDa Protein; Peroxiredoxin-6; 1-Cys Peroxiredoxin; Antioxidant Protein 2; Liver 2D Page Spot 40

Product Type: Polyclonal Antibody

Immunogen: Recombinant human Peroxiredoxin 6 protein purified from E. coli.

Applications: WB

Species Crossreactivity: Human, Mouse, Rat

Concentration: 0.5 mg/ml

Formulation: Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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Literature References: 1) Wood, Z. A. et al. (2003) Trends Biochem Sci. 28(1):32-40. (General) | 2) Angelika Tolle, et al. (2005) Free Radic Biol Med. 38:1401-0108. (General)