anti-Antithrombin 3, mAb (8C12)

Product description: Monoclonal Antibody. Recognizes the Human protein. Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. Antithrombin III is a plasma protein synthesized in the liver and has molecular weight of 58kDa. Antithrombin III is a heparin-binding glycoprotein that acts as the major inhibitor of thrombin. Also it interferes with several plasma proteases, including kallikrein and factors IXa, Xa, XIa and XIIa, thereby playing a central role in regulating coagulation. It is also used as a therapeutic agent in patients with sepsis and disseminated intravascular coagulation. In addition, a number of recent studies have shown that antithrombin III has anti-inflammatory properties, which are independent of its effects on coagulation. Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin.

Alternate Names/Synonyms: AT3; ATIII; PRO0309; SERPINC1; Serpin C1; Antithrombin-III

Product Type: Monoclonal Antibody

Clone: 8C12

Isotype: Mouse IgG1 kappa

Immunogen: Antithrombin III protein purified from human plasma.

Applications: ELISA, WB

Species Crossreactivity: Human

Formulation: Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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Literature References: 1) Hajime Saito, et. al (2005) Journal of Leukocyte biology 78, 777-784. (General)