AVANTI POLAR LIPIDS , CYGNUS , LARODAN , ADIPOGEN , MYBIOSOURCE , SERVA NORDMARK, BIOWORLD, EDGEBIO , PANREAC APPLICHEM
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Product description: Monoclonal Antibody. Recognizes the Human protein. Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. Attractin is a serum glycoprotein of 175 kDa and found in both membrane-bound and secreted forms as a result of alternative splicing. Both the secreted and membrane-bound forms of attractin may be involved in the development and maintenance of the central nervous system. Membrane-bound attractin is a co-receptor for Agouti, antagonist of melanocortin-1 receptor. Secreted attractin, expressed by activated T lymphocytes and modulates interactions between T cells and monocytes/macrophages, was examined as a potential marker of immune activity. Attractin may be a component of a pathway for regulated protein turnover that also involves mahogunin, a wide-expressed E3 ubiquitin ligase found at particularly high levels in the brain. Attractin was considered as an extracellular target amenable for the development of obesity-regulating drugs, also. Involved in the initial immune cell clustering during inflammatory response and may regulate chemotactic activity of chemokines. May play a role in melanocortin signaling pathways that regulate energy homeostasis and hair color. Low-affinity receptor for agouti. Has a critical role in normal myelination in the central nervous system
Alternate Names/Synonyms: ATRN; DPPT-L; KIAA0548; Attractin; Mahogany Homolog
Product Type: Monoclonal Antibody
Isotype: Mouse IgG1 kappa
Immunogen: Protein purified from human plasma.
Applications: IP, WB
Species Crossreactivity: Human
Formulation: Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Short Term Storage: +4°C
Long Term Storage: -20°C
Shipping: BLUE ICE
Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.
Literature References: 1) Duke-Cohan, J. S. et al, PNAS (1998), vol.95 (19): pp.11336~11341. (General)2) He, L. et al, Nature Genetics (2001) vol.27: pp.40~47. (General)3) Duke-Cohan, J. S. et al, J Environ Pathol Toxicol Oncol. (2004) vol. 23: pp.1~11. (General)
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