AVANTI POLAR LIPIDS , CYGNUS , LARODAN , ADIPOGEN , MYBIOSOURCE , SERVA NORDMARK, BIOWORLD, EDGEBIO , PANREAC APPLICHEM
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Product description: Monoclonal Antibody. Recognizes the Human, Mouse, Rat protein. Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. Aurora protein kinase family (consisting of Aurora-A, -B and -C) is an important group of enzymes that controls several aspects of cell division in mammalian cells. In humans, Aurora-A is localized to the centrosome in prophase, subsequently spreading to the mitotic spindles/centrosomes. Aurora-B is found at the kinetochore, mainly at the midzone, during anaphase. Aurora-C is localized to the centrosomes from anaphase to cytokinesis. Aurora B is the catalytic component of the chromosomal passenger complex, which is composed of three additional noncatalytic subunits that direct its activity: survivin, INCEP, and borealin. Aurora B appears to be required for several mitotic processes, including aberrant chromosome alignment/segregation and cytokinesis. Phosphorylation of Histone H3 (Ser10 and Ser28) by Aurora B contributes to chromosome number instability and mitotic chromosome condensation. May be directly involved in regulating the cleavage of polar spindle microtubules and is a key regulator for the onset of cytokinesis during mitosis. Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Phosphorylates 'Ser-10' and 'Ser-28' of histone H3 during mitosis. Required for kinetochore localization of BUB1.
Alternate Names/Synonyms: AIK2; AURKB; AIM-1; ARK-2; STK-1; Aurora 1; EC=18.104.22.168; Aurora Kinase B; Aurora-related Kinase 2; Aurora/IPL1-related Kinase 2; Serine/Threonine-Protein Kinase 5; Serine/Threonine-Protein Kinase 12
Product Type: Monoclonal Antibody
Isotype: Mouse IgG2a kappa
Immunogen: Recombinant human His-Aurora B protein purified from E. coli.
Applications: ELISA, WB
Species Crossreactivity: Human, Mouse, Rat
Formulation: Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Short Term Storage: +4°C
Long Term Storage: -20°C
Shipping: BLUE ICE
Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.
Literature References: 1) Vader G and Lens SM, (2008) Biochim Biophys Acta 1786(1):60-72. (General)2) Gautschi O, (2008) Clin Cancer Res 14(6):1639-48. (General)3) Hauf S et al. (2003) J Cell Biol 161,281-94. (General)
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