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5 mg

Ref. SYN-1117-M005
SYNKINASE
1187595-84-1

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Neuf 329.00 H.T.

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Détails Produit

Product description: Chemical. CAS: 1187595-84-1. Formula: C16H17N7O2S . H3PO4. MW: 371.4 . 98.0. Baricitinib is a selective JAK1 and JAK2 inhibitor. IC(50) values are 5.9nm for JAK1, and 5.7nM for JAK2. In cell based assays Baricitinib/INCB-28050 demonstrated inhibition of intracellular signaling of multiple pro-inflammatory cytokines including IL-6 and IL-23 at concentrations of < 50nM, and also showed good efficacy in a number of animal models at doses of 10mg/kg and below. Baricitinib is in Phase III development as a potential treatment for rheumatoid arthritis. It is in Phase II development as a potential treatment for psoriasis and diabetic nephropathy

Alternate Names/Synonyms: LY-3009104; INCB-28050

Product Type: Chemical

Molecular Formula: C16H17N7O2S . H3PO4

Molecular Weight: 371.4 . 98.0

CAS: 1187595-84-1

Purity: >95%

InChiKey: FBPOWTFFUBBKBB-UHFFFAOYSA-N

Appearance: Solid.

Solubility: Soluble in DMSO or ethanol.

Short Term Storage: +4°C

Long Term Storage: -20°C

Long Shipping: AMBIENT

Use & Stability: Stable for at least 2 years after receipt when stored at -20°C.

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