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AVANTI POLAR LIPIDS , CYGNUS , LARODAN , ADIPOGEN , MYBIOSOURCE , SERVA NORDMARK, BIOWORLD, EDGEBIO , PANREAC APPLICHEM
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Baricitinib phosphate salt
10 mg
photos non contractuelles
Détails Produit
Product description: Chemical. CAS: 1187595-84-1. Formula: C16H17N7O2S . H3PO4. MW: 371.4 . 98.0. Baricitinib is a selective JAK1 and JAK2 inhibitor. IC(50) values are 5.9nm for JAK1, and 5.7nM for JAK2. In cell based assays Baricitinib/INCB-28050 demonstrated inhibition of intracellular signaling of multiple pro-inflammatory cytokines including IL-6 and IL-23 at concentrations of < 50nM, and also showed good efficacy in a number of animal models at doses of 10mg/kg and below. Baricitinib is in Phase III development as a potential treatment for rheumatoid arthritis. It is in Phase II development as a potential treatment for psoriasis and diabetic nephropathy
Alternate Names/Synonyms: LY-3009104; INCB-28050
Product Type: Chemical
Molecular Formula: C16H17N7O2S . H3PO4
Molecular Weight: 371.4 . 98.0
CAS: 1187595-84-1
Purity: >95%
InChiKey: FBPOWTFFUBBKBB-UHFFFAOYSA-N
Appearance: Solid.
Solubility: Soluble in DMSO or ethanol.
Short Term Storage: +4°C
Long Term Storage: -20°C
Long Shipping: AMBIENT
Use & Stability: Stable for at least 2 years after receipt when stored at -20°C.
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