anti-BEDF, mAb (PK33-5B8)

Product description: Dual specificity phosphatase 13 (Also known as BEDP; MDSP; TMDP; SKRP4; DUSP13A; DUSP13B) is an enzyme that in humans is encoded by the DUSP13 gene. Members of the protein tyrosine phosphatase superfamily cooperate with protein kinases to regulate cell proliferation and differentiation. This superfamily is separated into two families based on the substrate that is dephosphorylated. One family, the dual specificity phosphatases (DSPs) acts on both phosphotyrosine and phosphoserine/threonine residues. This gene encodes different but related DSP proteins through the use of non-overlapping open reading frames, alternate splicing, and presumed different transcription promoters. Expression of the distinct proteins from this gene has been found to be tissue specific and the proteins may be involved in postnatal development of specific tissues. A protein encoded by the upstream ORF was found in skeletal muscle, whereas the encoded protein from the downstream ORF was found only in testis. In mouse, a similar pattern of expression was found. Multiple alternatively spliced transcript variants were described, but the full-length sequence of only some were determined. May be involved in the regulation of meiosis and/or differentiation of testicular germ cells during spermatogenesis. Exhibits intrinsic phosphatase activity towards both phospho-seryl/threonyl and -tyrosyl residues of myelin basic protein, with similar specific activities in vitro.

Alternate Names/Synonyms: BEDP; MDSP; DUSP13; DUSP13A; EC=3.1.3.16; EC=3.1.3.48; Muscle-restricted DSP; Branching-enzyme Interacting DSP; Dual Specificity Protein Phosphatase 13 Isoform A

Product Type: Monoclonal Antibody

Clone: PK33-5B8

Isotype: Mouse IgG2b

Immunogen: Recombinant human protein purified from E. coli.

Applications: IP, WB

Species Crossreactivity: Human

Formulation: Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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