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50 mg

Ref. SYN-1018-M050

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Neuf 198.00 H.T.


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Détails Produit

Product description: NVP-BEZ235 is an imidazo[4,5-c]quinoline derivative that inhibits PI3K and mTOR kinase activity by binding to the ATP-binding cleft of these enzymes. In cellular settings using human tumor cell lines, this molecule is able to effectively and specifically block the dysfunctional activation of the PI3K pathway, inducing G1 arrest at IC(50) values 3-10nM in biological cell growth and viability assays. In addition NVP-BEZ235 shows effective IC(50) values in in vitro tests against mTor and PI3K family members of 10nM.

Alternate Names/Synonyms: NVP-BEZ235; BEZ-235

Product Type: Chemical

Molecular Formula: C30H23N5O

Molecular Weight: 469.6

CAS: 915019-65-7

Purity: >95%


Appearance Solid.

Solubility: Soluble in DMSO or ethanol.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: AMBIENT

Use & Stability: Stable for at least 2 years after receipt when stored at -20°C.

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