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AVANTI POLAR LIPIDS , CYGNUS , LARODAN , ADIPOGEN , MYBIOSOURCE , SERVA NORDMARK, BIOWORLD, EDGEBIO , PANREAC APPLICHEM
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BEZ235
100 mg
photos non contractuelles
Détails Produit
Product description: NVP-BEZ235 is an imidazo[4,5-c]quinoline derivative that inhibits PI3K and mTOR kinase activity by binding to the ATP-binding cleft of these enzymes. In cellular settings using human tumor cell lines, this molecule is able to effectively and specifically block the dysfunctional activation of the PI3K pathway, inducing G1 arrest at IC(50) values 3-10nM in biological cell growth and viability assays. In addition NVP-BEZ235 shows effective IC(50) values in in vitro tests against mTor and PI3K family members of 10nM.
Alternate Names/Synonyms: NVP-BEZ235; BEZ-235
Product Type: Chemical
Molecular Formula: C30H23N5O
Molecular Weight: 469.6
CAS: 915019-65-7
Purity: >95%
InChiKey: JOGKUKXHTYWRGZ-UHFFFAOYSA-N
Appearance Solid.
Solubility: Soluble in DMSO or ethanol.
Short Term Storage: +4°C
Long Term Storage: -20°C
Shipping: AMBIENT
Use & Stability: Stable for at least 2 years after receipt when stored at -20°C.
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