anti-BMP4, pAb

Product description: Polyclonal Antibody. Recognizes the Human, Mouse protein. Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. Bone morphogenetic protein 4, also known as BMP4, is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo. BMPs also regulate cell proliferation, differentiation, lineage determination, motility, and death. BMP4 is a potent bone-inducing morphogen, and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. BMP4 is a critical signaling molecule required for the early differentiation of the embryo and establishing of a dorsal-ventral axis. It also plays a role in the epithelial-mesenchymal interactions leading to tooth formation. Both BMP2 and BMP4 have been found in calcified atherosclerotic plaques and aortic valve diseases, which suggests their importance in cardiovascular diseases. Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair.

Alternate Names/Synonyms: BMP4; BMP2B; BMP-4; BMP-2B; Bone Morphogenetic Protein 4; Bone Morphogenetic Protein 2B

Product Type: Polyclonal Antibody

Immunogen: Synthetic peptide.

Applications: WB

Species Crossreactivity: Human, Mouse

Concentration: 1 mg/ml

Formulation: Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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Literature References: 1) Chang KH et al. (2007) Circulation. 116:1258-1266. (General)2) Yanagita M, (2005) Cytokine Growth Factor Rev. 16(3):309-317. (General)3) Canalis E et al. (2003) Endocr Rev. 2003 24(2):218-235. (General)