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100 µl

Ref. YIF-LF-MA0191

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Neuf 331.00 H.T.


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Détails Produit

Product description: Monoclonal Antibody. Recognizes the Human protein. Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. Btk (Bruton's tyrosine kinase) is a member of the Tec family of protein tyrosine kinases (PTKs) and plays a modulatory role in many cellular processes, such as proliferation, development, differentiation, survival, and apoptosis. The Tec kinases are the second largest family of non-receptor tyrosine kinases and include Tec, Btk, Bmx, Itk, and TXK/Rlk. Mutations of Btk gene cause a primary immunodeficiency disease in humans, X-linked agammaglobulinemia (XLA) which is characterized by a lack of circulating B lymphocytes and an absence of immunoglobulins as a result of defects in B cell maturation and function. Btk is found in all hematopoietic cells, with the exception of T lymphocytes and plasma cells. Btk contains amino-terminal PH (pleckstrin homology) domain which binds phosphatidylinositol (3,4,5)-trisphosphate (PIP3) helping membrane translocation upon PI3 kinase activation. The Tec kinases have similar structure of N-terminal PH domains followed by Tec homology (TH), Src homology 3 (SH3), Src homology 2 (SH2), and kinase domains. Autophosphorylation of Tyr223 in SH3 domain is necessary for full activation of Btk. Various binding proteins have been reported to interact with different domains of Btk. Plays a crucial role in B-cell ontogeny. Transiently phosphorylates GTF2I on tyrosine residues in response to B-cell receptor cross-linking. Required for the formation of functional ARID3A DNA-binding complexes.

Alternate Names/Synonyms: BPK; ATK; BTK; AGMX1; EC=; Bruton Tyrosine Kinase; B-Cell Progenitor Kinase; Tyrosine-Protein Kinase BTK; Agammaglobulinemia Tyrosine Kinase

Product Type: Monoclonal Antibody

Clone: 1A1

Isotype: Mouse IgG1 kappa

Immunogen: Recombinant human His/ABD-Btk protein purified from E. coli.

Applications: ELISA, IHC, WB

Species Crossreactivity: Human

Formulation: Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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Literature References: 1) Lindvall J.M. et al. (2005) Immunol Rev. 203:200-215. (General)2) Jefferies C.A. and O’Neill L.A. (2004) Immunol Lett. 92:15-22. (General)3) Smith C.I. et al. (2001) Bioessays, 23:436-446. (General)4) Schaeffer E.M. and Schwartzberg P.L. (2000) Curr Opin Immunol. 12:282-288. (General)