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100 µg

Ref. CHI-HF-210BTNL2-C100
CHIMERIGEN
https://adipogen.com

photos non contractuelles

Neuf 600.00 H.T.

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Détails Produit

Product Description: Butyrophilin-like 2 (BTNL2) is a butyrophilin family member with homology to the B7 costimulatory molecules, polymorphisms of which have been recently associated through genetic analysis; to sporadic inclusion body myositis and sarcoidosis. BTNL2 mRNA is highly expressed in lymphoid tissues as well as in intestine. BTNL2-Ig fusion protein was shown to recognize a putative receptor whose expression on B and T cells was significantly enhanced after activation. It inhibited T cell proliferation and TCR activation of NFAT, NF-kappaB and AP-1 signaling pathways. BTNL2 is the first member of the butyrophilin family that regulates T cell activation, which has implications in immune diseases and immunotherapy.

Alternate Names/Synonyms: Butyrophilin-like Protein 2; BTN7

Product type: Protein

Source / Host: HEK 293 cells

Sequence: The extracellular domain of human BTNL2 (aa 24-455) is fused to the N-terminus of the Fc region of human IgG1.

Species Crossreactivity: Human

Molecular Weight: ~74kDa (monomer)

TAGs: Fc

Purity: >98% (SDS-PAGE)

Endotoxin: <0.06EU/µg protein (LAL test; Lonza).

Formulation: Lyophilized from 0.2µm-filtered solution in PBS.

Handling Advice: Avoid freeze/thaw cycles.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.

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