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100 µl

Ref. YIF-LF-MA0320
AB FRONTIER

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Neuf 331.00 H.T.

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Détails Produit

Product description: Monoclonal Antibody. Recognizes the Human protein. Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. Cathepsin D (CatD) is a ubiquitously expressed lysosomal aspartyl protease involved in the normal degradation of proteins apoptosis and autophagy. Human CatD is synthesized on the endoplasmic reticulum as a pre-pro-enzyme. Preprocathepsin D (412aa) is cleaved and glycosylated to form an inactive procathepsin D (392aa) and then further cleaved to generate an active intermediate (348aa) single-chain molecule. The active intermediate is further processed into mature two chain form of cathepsin D, this processing step is carried out by cathepsin B or L. The two-chain form consists of an amino terminal light chain and a carboxyl-terminal heavy chain. Additionally, several more amino acids are removed from the carboxyl terminus of the heavy chain. Procathepsin D (pCD), secreted from cancer cells, acts as a mitogen on both cancer and stromal cells and stimulates their proinvasive and pro-metastatic properties. Acid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease

Alternate Names/Synonyms: CPSD; CTSD; EC=3.4.23.5

Product Type: Monoclonal Antibody

Clone: AF1C7

Isotype: Mouse IgG1 kappa

Immunogen: Recombinant human His-Cathepsin D protein purified from E. coli.

Applications: WB

Species Crossreactivity: Human

Formulation: Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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Literature References: 1) Zaidi N et al. (2008) Biochem Biophys Res Commun 7;376(1):5-9. (General)2) Liaudet-Coopman E et al. (2006) Cancer Lett 237;167-179. (General)