CCL2 (human):Fc (human) (rec.)

Product Description: CCL2, also called monocyte chemotactic protein-1 (MCP-1), is a member of the C-C or beta chemokine family that is best known as a chemotactic agent for mononuclear cells. Fibroblasts, glioma cells, smooth muscle cells, endothelial cells, lymphocytes and mononuclear phagocytes can produce CCL2 either constitutively or upon mitogenic stimulation, but monocytes and macrophages appear to be the major source. In addition to its chemotactic activity, CCL2 induces enzyme and cytokine release by monocytes, NK cells and lymphocytes, and histamine release by basophils that express its receptor CCR2. Additionally, it promotes Th2 polarization in CD4+ T cells. CCL2-mediated recruitment of monocytes to sites of inflammation is proposed to play a role in the pathology of atherosclerosis, multiple sclerosis and allergic asthma.

Alternate Names/Synonyms: C-C Motif Chemokine 2; HC11; MCAF; Monocyte Chemotactic and Activating Factor; MCP1; Monocyte Chemotactic Protein 1; Scya2; Small-inducible Cytokine A2; JE; Monocyte Secretory Protein JE; SMC-CF; Sigje

Product type: Protein

Source / Host: CHO cells

Sequence: The extracellular domain of human CCL2 (aa 24-99) is fused to the N-terminus of the Fc region of human IgG1.

Species Crossreactivity: Human

TAGs: Fc

Purity: >98% (SDS-PAGE)

Endotoxin: <0.06EU/µg protein (LAL test; Lonza).

Formulation: Lyophilized from 0.2µm-filtered solution in PBS.

Handling Advice: Avoid freeze/thaw cycles.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.

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