CCL4 (human):Fc (human) (rec.)

Product Description: CCL4, (C-C motif chemokine 4; macrophage inflammatory protein 1beta) is a chemokine secreted at sites of inflammation by activated leukocytes, lymphocytes, vascular endothelial cells and pulmonary smooth cells. CCL4 attracts a variety of immune cells to sites of microbial infection as well as to pathologic inflammation, such as allergic asthma and ischemic myocardium. Full-length and truncated CCL4 exert biological activity through the receptor CCR5. The truncated form of CCL4 interacts additionally with CCR1 and CCR2b. The ability of CCL4 to bind CCR5 inhibits the cellular entry of M-tropic HIV. Both CCL4 forms block HIV-1 infection of T cells by inducing the downregulation of CCR5.

Alternate Names/Synonyms: C-C Motif Chemokine 4; Lymphocyte Activation Gene 1 Protein; LAG-1; Macrophage Inflammatory Protein 1beta; MIP-1beta; T Cell Activation Protein 2; ACT-2; Small-inducible Cytokine A4; PAT 744; Protein H400

Product type: Protein

Source / Host: CHO cells

Sequence: The extracellular domain of human CCL4 (aa 24-92) is fused to the N-terminus of the Fc region of human IgG1.

Species Crossreactivity: Human

TAGs: Fc

Purity: >98% (SDS-PAGE)

Endotoxin: <0.06EU/µg protein (LAL test; Lonza).

Formulation: Lyophilized from 0.2µm-filtered solution in PBS.

Handling Advice: Avoid freeze/thaw cycles.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.

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