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100 µl

Ref. YIF-LF-MA0116
AB FRONTIER

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Neuf 331.00 H.T.

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Détails Produit

Product description: Monoclonal Antibody. Recognizes the Human, Mouse, Rat protein. Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. Cyclin-dependent kinase-5 (CDK5) is a member of the cyclin-dependent kinase family of serine/threonine kinases. Its mRNA and protein are expressed in kidney, testes, and ovary. And Its activity is detected almost exclusively in brain extracts. Similar to other Cdks, monomeric Cdk5 displays no enzymatic activity, but Cdk5 is not activated by cyclins. Instead, Cdk5 activity requires association with one of two brain-specific regulatory subunits called p35 and p39. The two activators regulate the spatial and temporal expression of active Cdk5 to restrict its activity primarily to post-mitotic neurons. Probably involved in the control of the cell cycle. Interacts with D1 and D3-type G1 cyclins. Can phosphorylate histone H1, tau, MAP2 and NF-H and NF-M. Also interacts with p35 which activates the kinase.

Alternate Names/Synonyms: CDK5; CDKN5; EC=2.7.11.22; TPKII Catalytic Subunit; Cyclin-dependent Kinase 5; Cell Division Protein Kinase 5; Tau Protein Kinase II Catalytic Subunit; Serine/Threonine-Protein Kinase PSSALRE

Product Type: Monoclonal Antibody

Clone: 8A1

Isotype: Mouse IgG2b kappa

Immunogen: Recombinant human His-CDK5 protein purified from baculovirus expressed insect cells.

Applications: ELISA, IP, WB

Species Crossreactivity: Human, Mouse, Rat

Formulation: Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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Literature References: 1) Shirley B. Shelton and Gail V.W. Johnson (2004) Journal of Neurlchemistry 88,1313-1326. (General)2) Jonathan C Cruz and Li-Huei Tsai (2004) Current Poinion in Neurobiology 14:390-394. (General)3) Deanna S. Smith, et al. (2001) Cell Growth & Differentiation 12,277-283. (General)