anti-CDK6, mAb (75B9)

Product description: Monoclonal Antibody. Recognizes the Human protein. Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. Cyclin-dependent kinase 6 (CDK6) is a 40 kDa member of the CDK family of mitotic kinases involved in cell cycle progression. CDKs are the catalytic subunits of the cyclin/CDK complexes, which phosphorylate substrates on threonine/serine residues. CDK6 associates with the D-type cyclins and is important in the progression of cells from the G1-phase to the S-phase of the cell cycle. Loss of normal cell cycle regulation is the hallmark of human cancers, and alteration of the components involved in cell cycle regulation occurs in most human tumors. This suggests that CDK6 is an attractive target for the development of pharmacological agents for the treatment of cancer. Recently, several studies have indicated a novel role for cdk6 in differentiation, also. Probably involved in the control of the cell cycle. Interacts with D-type G1 cyclins.

Alternate Names/Synonyms: CDK6; CDKN6; EC=2.7.11.22; Cyclin-dependent Kinase 6; Cell Division Protein Kinase 6; Serine/Threonine-Protein Kinase PLSTIRE

Product Type: Monoclonal Antibody

Clone: 75B9

Isotype: Mouse IgG2b kappa

Immunogen: Recombinant human protein purified from E. coli.

Applications: ELISA, WB

Species Crossreactivity: Human

Formulation: Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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Literature References: 1) Grossel MJ, Hinds PW, J Cell Biochem. (2006) vol.97(3): pp.485-93. (General)2) Grossel MJ, Hinds PW, Cell Cycle. (2006) vol.5(3): pp.266-70. (General)3) Hirai H et al, Curr Top Med Chem. (2005) vol.5(2): pp.167-79. (General)