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100 µl

Ref. YIF-LF-MA0296
AB FRONTIER

photos non contractuelles

Neuf 331.00 H.T.

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Détails Produit

Product description: Monoclonal Antibody. Recognizes the Human, Mouse, Rat protein. Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. Cofilin belongs to a family of related proteins with similar biochemical activities called the actin depolymerizing factor (ADF)/cofilin family. ADF/cofilins play an important role in cytokinesis , endocytosis, and in the development of all embryonic tissues. Cofilin is a small ubiquitous protein (~19 kDa) that is able to bind both G-actin (monomeric) and F-actin(filamentous actin). Cofilin promotes the regeneration of actin filaments by severing pre-existing filaments. LIMK or TESK play a central role in the regulation of the actin cytoskeleton by phosphorylating cofilin on Ser3. Phosphorylation of cofilin at Ser3 inhibits its ability to bind to actin. Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods.

Alternate Names/Synonyms: CFL; p18; CFL1; Cofilin-1; 18 kDa Phosphoprotein; Cofilin; Non-muscle Isoform

Product Type: Monoclonal Antibody

Clone: AF2C2

Isotype: Mouse IgG2a kappa

Immunogen: Recombinant human His-cofilin protein purified from E. coli.

Applications: ELISA, WB

Species Crossreactivity: Human, Mouse, Rat

Formulation: Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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Literature References: 1) Wang W, Eddy R, Condeelis J, (2007) Nat Rev Cancer 7(6):429-40. (General)2) Condeelis, J, (2001) Trends Cell Biol 11, 288-293. (General)3) Scott RW and Olson MF, (2007) J Mol Med 85(6):555-68. (General)