anti-Coilin, mAb (1H10)

Product description: Monoclonal Antibody. Recognizes the Human protein. Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. Coilin is a component of the nuclear Cajar (coiled) bodies (CBs) which are involved in the function or assembly/disassembly of nucleoplasmic snRNPs. Human coilin is a 576-amino acid protein found enriched in CBs, but is also found in large amounts in the nucleoplasm. Coilin is a constitutive phosphoprotein that is hyperphosphorylated during mitosis and it is thought that hyperphosphorylation triggers CB disassembly during cell replication. Self-interaction and localization have been shown to depend on the phosphorylation state of coilin Is a component of the nuclear coiled bodies (CBS) which are involved in the function or assembly/disassembly of nucleoplasmic snRNPs. During mitosis, CBS disassemble, coinciding with a mitotic-specific phosphorylation of p80 coilin.

Alternate Names/Synonyms: p80; COIL; CLN80; Coilin

Product Type: Monoclonal Antibody

Clone: 1H10

Isotype: Mouse IgG2b kappa

Immunogen: Recombinant human His-Coilin protein purified from E. coli.

Applications: WB

Species Crossreactivity: Human

Formulation: Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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Literature References: 1) Lam YW, Lyon CE, Lamond AI. (2002) Mol.Biol.Cell. 13:2461–2473. (General)2) Carmo-Fonseca M. Et al. (1993) J Cell Biol. 120:841–852. (General)