anti-Complement Factor C8 beta Propeptide, mAb (14A10)

Product description: Monoclonal Antibody. Recognizes the Human protein. Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. The complement system is a part of the larger immune system and three biochemical pathways are present: the classical complement pathway, the alternative pathway, and the mannose-binding lectin pathway. Human complement factor C8 is one of five components (C5b, C6, C7, C8, and C9) that interact to form the cytolytic membrane attack complex (MAC) which is the cytolytic end product of the complement cascade. MAC is typically formed on the surface of intruding pathogenic bacterial as a result of the activation of the complement system, and it is one of the ultimate weapons of the immune system. C8 is composed of an alpha (64 kDa), beta (64 kDa), and gamma (22 kDa) subunit. Within C8, the subunits are arranged as a disulfide-linked C8 alpha-gamma heterodimer that is noncovalently associated with C8 beta. During MAC formation, C8 alpha mediates binding and self-polymerization of C9 to form a pore-like structure on the membrane of target cells. Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.

Alternate Names/Synonyms: C8B; Complement Component C8 beta Chain; Complement Component 8 Subunit beta

Product Type: Monoclonal Antibody

Clone: 14A10

Isotype: Mouse IgG1 kappa

Immunogen: Protein purified from human plasma.

Applications: ELISA, IP, WB

Species Crossreactivity: Human

Formulation: Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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Literature References: 1) Scibek, J.J. et al. (2002) Biochemistry. 41:14546-14551. (General)2) Esser, A. F. (1994) Toxicology 87:229-247. (General)3) Muller-Eberhard, H. J. (1988) Annu. ReV. Biochem. 57:321-347. (General)