anti-Complement Factor C9, mAb (64E9)

Product description: Monoclonal Antibody. Recognizes the Human protein. Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. Complement factor C9, 71kDa, is the last of the human complement components creating the membrane attack complex (MAC). Activation of the complement system leads to the formation of the MAC, which in turn causes lysis, and death of target cells. C9 plays an important role in inflammatory reactions since it is essential for lytic action of the MAC. Such lytic action could be the basis for complement autotoxicity. Like most of the complement components, C9 belongs to the acute-phase proteins which are generally of hepatic origin, and their plasma concentrations increase (or decrease) following tissue injury and inflammation. Also, because C9 is required for the MAC of complement to become functional, interfering with signaling pathways that stimulate its production could offer new therapeutic strategies for treating various neurodegenerative disorders. Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C9 is the pore-forming subunit of the MAC.

Alternate Names/Synonyms: C9

Product Type: Monoclonal Antibody

Clone: 64E9

Isotype: Mouse IgG1 kappa

Immunogen: Protein purified from human plasma.

Applications: WB

Species Crossreactivity: Human

Formulation: Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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Literature References: 1) Stanley KK. Curr Top Microbiol Immunol. (1989) vol.140: pp.49-65. (General)2) Klegeris A, et al, Exp Gerontol. (2001) vol.36(7): pp.1179-88. (General)3) Witzel-Schlomp K, et al, Eur J Immunogenet. (2001) vol.28(5): pp.515-22. (General)