anti-Complement Factor H, mAb (63G5)

Product description: Monoclonal Antibody. Recognizes the Human protein. Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. The complement system is a crucial component of the innate immunity against microbial infection. Complement factor H, a 155 kDa plasma glycoprotein, is an essential regulatory protein that plays a critical role in the homeostasis of the complement system in plasma and in the protection of bystander host cells and tissues from damage by complement activation. Factor H binds to C3b, accelerates the decay of the alternative pathway C3-convertase and acts as a cofactor for the factor I-mediated proteolytic inactivation of C3b. In addition, factor H has multiple physiological activities 1) acts as an extracellular matrix component, 2) binds to cellular receptors of the integrin type, and 3) interacts with a wide selection of ligands, such as the C-reactive protein, thrombospondin, bone sialoprotein, osteopontin, and heparin. Complement factor H has revealed an association with two different renal diseases, glomerulonephritis and atypical hemolytic uremic syndrome (aHUS). Factor H functions as a cofactor in the inactivation of C3b by factor I and also increases the rate of dissociation of the C3bBb complex (C3 convertase) and the (C3b)NBB complex (C5 convertase) in the alternative complement pathway.

Alternate Names/Synonyms: HF; CFH; H Factor 1; Complement Factor H

Product Type: Monoclonal Antibody

Clone: 63G5

Isotype: Mouse IgG2b kappa

Immunogen: Protein purified from human plasma.

Applications: ELISA, IP

Species Crossreactivity: Human

Formulation: Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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Literature References: 1) Ripoche, J. et al (1988) Biochem J 249: 593-602. (General)2) Pangburn M. K. et al (2000) J. Immunol. 164: 4742-4751. (General)3) Rodriguez de Cordoba S, et al, (2004) Mol Immunol. vol.41(4): pp.355-67. (General)4) Zipfel PF. (2001) Semin Thromb Hemost. vol.27(3): pp.191-9. (General)