anti-Connexin 43, pAb

Product description: Polyclonal Antibody. Recognizes the Human, Mouse, Rat protein. Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. Connexin 43 (Cx43) is a widely expressed gap junction protein that mediates communication between many cell types. Gap junctions are implicated in tissue homeostasis and control of cell proliferation and differentiation. Connexin 43 is predominantly localized at the sarcolemma, where six connexins assemble into a so-called connexon or hemichannel. Clusters of these channels assemble to make gap junctions. Cx43 is a target protein of several kinases, among them PKA, PKC, PKG, MAPK, and casein kinase, but also for protein phosphatases. The phosphorylation of Cx43 at Ser368 by PKC induces a closure of Hemichannels. Src can phosphorylate Cx43 to alter gap junction communication. One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph.

Alternate Names/Synonyms: GJAL; Cx43; GJA1; Connexin-43; Gap Junction alpha-1 Protein; Gap Junction 43 kDa Heart Protein

Product Type: Polyclonal Antibody

Immunogen: Synthetic peptide.

Applications: WB

Species Crossreactivity: Human, Mouse, Rat

Concentration: 1 mg/ml

Formulation: Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50%glycerol.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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Literature References: 1) Pahujaa M et al. (2007) Exp Cell Res 313(20):4083-90. (General)2) Schulz R et al. (2007) Heart Fail Rev 12(3-4):261-6. (General)3) Solan JL and Lampe PD, (2005) Biochim Biophys Acta 10;1711(2):154-63. (General)