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100 µl

Ref. YIF-LF-PA0203
AB FRONTIER

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Neuf 331.00 H.T.

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Détails Produit

Product description: Polyclonal Antibody. Recognizes the Human, Rat protein. Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. Cortactin is a ubiquitous actin-binding protein that was originally identified as a substrate for Src. It is accumulated in peripheral, actin-enriched structures of cells, including lamellipodia and membrane ruffles, suggesting that cortactin facilitates actin network formation. Cortactin has four major domains of interest:the N-terminal acidic (NTA) and tandem repeats domains, and the C-terminal proline-rich and SH3 Domains. NTA associates with the Arp2/3 and WASP complex at F-actin branches. Cortactin is involved in promoting cell motility and invasion, including a critical role in invadopodia, actin rich-subcellular protrusions associated with degradation of the ECM by cancer cells. Cortactin is phosphorylated by src family kinases at Y421, Y466, and Y482 and S405 and S418 that are phosphorylated by Erk family kinases. May contribute to the organization of cell structure. The SH3 motif may function as a binding region to cytoskeleton. Tyrosine phosphorylation in transformed cells may contribute to cellular growth regulation and transformation.

Alternate Names/Synonyms: EMS1; CTTN; Amplaxin; Oncogene EMS1; Src Substrate Cortactin

Product Type: Polyclonal Antibody

Immunogen: Synthetic peptide.

Applications: WB

Species Crossreactivity: Human, Rat

Concentration: 1 mg/ml

Formulation: Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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Literature References: 1) Ammer AG and Weed SA, (2008) Cell Motil Cytoskeleton 65(9):687-707. (General)2) Weaver AM, (2008) Cancer Lett 265(2):157-66. (General)3) Buday L and Downward J, (2007) Biochim Biophys Acta 1775(2):263-73. (General)