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100 µl

Ref. YIF-LF-MA0366

photos non contractuelles

Neuf 331.00 H.T.


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Détails Produit

Product description: Monoclonal Antibody. Recognizes the Mouse, Rat protein. Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. Cellular retinaldehyde-binding protein (CRALBP) is a cytoplasmic protein, abundantly expressed in the retinal pigment epithelium (RPE) and M°ller glia of the retina and in the pineal gland. Structurally, human CRALBP is a ?36-kDa monomeric protein, proposed to adopt an °open° or °closed° conformation, depending on whether it is carrying an endogenous ligand. CRALBP interacts structurally and functionally with 11-cis-retinol dehydrogenase (RDH5), an enzyme of the visual cycle in RPE. CRALBP is a member of the CRAL_TRIO family of proteins that share a lipid-binding domain derived from the yeast Sec14 protein. Mutations in the human CRALBP gene cause retinal pathology and delayed dark adaptation. CRALBP knockout mice have a delayed response in rhodopsin regeneration, 11-cis-retinal production and dark adaptation after illumination. Soluble retinoid carrier essential the proper function of both rod and cone photoreceptors. Participates in the regeneration of active 11-cis-retinol and 11-cis-retinaldehyde, from the inactive 11-trans products of the rhodopsin photocycle and in the de novo synthesis of these retinoids from 11-trans metabolic precursors. The cycling of retinoids between photoreceptor and adjacent pigment epithelium cells is known as the 'visual cycle'.

Alternate Names/Synonyms: RLBP1; CRALBP; Retinaldehyde-binding Protein 1; Cellular Retinaldehyde-binding Protein

Product Type: Monoclonal Antibody

Clone: 10A10

Isotype: Mouse IgG1 kappa

Immunogen: Recombinant human His-CRALBP protein purified from E. coli.

Applications: IP, WB

Species Crossreactivity: Mouse, Rat

Formulation: Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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Literature References: 1) Saari JC. Et al. (1978) J. Biol. Chem. 253(18)6432–6436. (General)2) Futterman S, Saari JC. (1977) Invest. Ophthalmol. Vis. Sci. 16(8)768–771. (General)3) Bunt-Milam AH, Saari JC. (1983) J. Cell Biol. 97(3)703–712. (General)4) Wu Z. Et al. (2004) J. Biol. Chem. 279(26)27357–27364. (General)5) Golovleva I. Et al. (2003) J. Biol. Chem. 278(14)12397–12402. (General)6) Panagabko C. Et al. (2003) Biochemistry 42(21) 6467–6474. (General)