AVANTI POLAR LIPIDS , CYGNUS , LARODAN , ADIPOGEN , MYBIOSOURCE , SERVA NORDMARK, BIOWORLD, EDGEBIO , PANREAC APPLICHEM
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Product description: Cellular retinaldehyde-binding protein (CRALBP) is a cytoplasmic protein, abundantly expressed in the retinal pigment epithelium (RPE) and Müller glia of the retina and in the pineal gland. Structurally, human CRALBP is a ?36-kDa monomeric protein, proposed to adopt an open or closed conformation, depending on whether it is carrying an endogenous ligand. CRALBP interacts structurally and functionally with 11-cis-retinol dehydrogenase (RDH5), an enzyme of the visual cycle in RPE. CRALBP is a member of the CRAL_TRIO family of proteins that share a lipid-binding domain derived from the yeast Sec14 protein. Mutations in the human CRALBP gene cause retinal pathology and delayed dark adaptation. CRALBP knockout mice have a delayed response in rhodopsin regeneration, 11-cis-retinal production and dark adaptation after illumination. Soluble retinoid carrier essential the proper function of both rod and cone photoreceptors. Participates in the regeneration of active 11-cis-retinol and 11-cis-retinaldehyde, from the inactive 11-trans products of the rhodopsin photocycle and in the de novo synthesis of these retinoids from 11-trans metabolic precursors. The cycling of retinoids between photoreceptor and adjacent pigment epithelium cells is known as the 'visual cycle'.
Alternate Names/Synonyms: RLBP1; CRALBP; Retinaldehyde-binding Protein 1; Cellular Retinaldehyde-binding Protein
Product Type: Monoclonal Antibody
Isotype: Mouse IgG1 kappa
Immunogen: Recombinant human His-CRALBP protein purified from E. coli.
Applications: IP, WB
Species Crossreactivity: Mouse, Rat
Formulation: Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Long Term Storage: -20°C
Shipping: BLUE ICE
Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.
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