anti-Cyclin D1, mAb (AF2G5)

Product description: Monoclonal Antibody. Recognizes the Human, Rat protein. Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. Cyclin D1 (Bcl-1 oncogene product), is a member of the Cyclin family that help control transition between phases of the cell cycle by acting as regulatory subunits of the Cdks. The D-type Cyclins are composed of three subtypes, Cyclin D1, D2 and D3. Cyclin D1 is essential for control of the cell cycle at the G1/S transitions and interacts with Cdk4 or Cdk6 protein kinases. On the recent study, Cyclin D1 regulates cellular metabolism, fat cell differentiation and cellular migration. Also Cyclin D1 involves in development and cancer. Essential for the control of the cell cycle at the G1/S (start) transition.

Alternate Names/Synonyms: BCL1; CCND1; BCL-1; BCL-1 Oncogene; PRAD1 Oncogene; G1/S-specific Cyclin-D1; B-Cell Lymphoma 1 Protein

Product Type: Monoclonal Antibody

Clone: AF2G5

Isotype: Mouse IgG1 kappa

Immunogen: Recombinant human His-Cyclin D1 protein purified from E. coli.

Applications: IP, WB

Species Crossreactivity: Human, Rat

Formulation: Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

Lien vers la Fiche Technique

Literature References: 1) Toru Motokura et al. (1992) J Biol Chem 267(28):20412-20415. (General)2) Xiang Zhang et al. (2005) Journal of Clinical Neuroscience 12(2):166-168. (General)3) Sherr CJ, (1993) Cell 73:1059-1065. (General)4) Hirofumi Nakagami et al. (2002) The Plant Cell 14:1847-1857. (General)