Cymax IL-6 (rat) ELISA Kit

Product description: Interleukin-6 (IL-6) is a pleiotropic alpha-helical cytokine that plays important roles in a central player in the regulation of inflammation, haematopoiesis, immune response and host defense mechanisms. Human IL-6 molecular weight ranges between 21 and 28 kDa, depending on the state of glycosylation and phosphorylation. Mature human IL-6 is 183 amino acids and shares the homology between human and rat IL-6 is 41% at the amino acid level. IL-6 interacts with its receptor complex consisting of the membrane-bound IL-6 receptor (IL-6R) and the signal transducing protein gp130. IL-6R can exist as a soluble protein (sIL-6R), which binds the ligand IL-6. This soluble complex can bind to gp130 on cells that lack the membrane-bound IL-6R and initiate signaling. Two major signalling pathways are activated by IL-6: the JAK/STAT pathway and MAPK cascade.

Alternate Names/Synonyms: Il6; IL-6; Il-6; Interleukin-6

Product Type: Kit

Crossreactivity: Rat

Sensitivity: 26.643 pg/ml

Range: 62.5 pg/ml - 4000 pg/ml

Sample Type: Rat Serum, Plasma, Cell Lysate, Culture Supernatants, Buffered Solution

Assay Type: Sandwich

Detection Type: Colorimetric

Short Term Storage: +4°C

Long Term Storage: +4°C

Shipping: BLUE ICE

Handling Advice Any unused reconstituted standard should be discarded or frozen at -80°C. Standard can be frozen and thawed one time only without loss of immunoreactivity.

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