anti-Diazepam Binding Inhibitor, mAb (27C9)

Product description: Monoclonal Antibody. Recognizes the Human protein. Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. Diazepam Binding Inhibitor(DBI) is a highly conserved 10 kDa polypeptide which is expressed in various species range from yeast to mammals. As an inverse agonist for benzodiazepine receptors, DBI downregulates inhibitory effects of GABA. It also has potential to induce anxiety. Found in central and peripheral tissues, DBI also participates in metabolism of steroids, which has been known to partially modify GABAA receptor function in the CNS. In peripheral tissues, DBI plays regulatory roles in steroidogenesis. DBI levels have been reported to be decreased in the cerebrospinal fluid obtained from patients with Alzheimer°s disease. Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor.

Alternate Names/Synonyms: EP; DBI; ACBP; Endozepine; Acyl-CoA-binding Protein; Diazepam-binding Inhibitor

Product Type: Monoclonal Antibody

Clone: 27C9

Isotype: Mouse IgG2b kappa

Immunogen: Recombinant human GST-fusion protein purified from E. coli.

Applications: ELISA, IHC, IP, WB

Species Crossreactivity: Human

Formulation: Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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Literature References: 1) Shoyab, M. et al (1986) J. Biol. Chem. 261: 11968-11973. (General)2) Gray, P.W. et al (1986) Proc. Nat. Acad. Sci. 83:7547-7551. (General)3) Ohkuma, S. et al (2001) Life Science 68: 1215-1222. (General)