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100 µl

Ref. YIF-LF-MA0134
AB FRONTIER

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Neuf 321.00 H.T.
en stock

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Détails Produit

Product description: Monoclonal Antibody. Recognizes the Human, Mouse, Rat protein. Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. ERK1 and ERK2 are widely expressed and are involved in the regulation of meiosis, mitosis, and postmitotic functions in differentiated cells. Many different stimuli, including growth factors, cytokines, virus infection, ligands for heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptors and transforming agents, activate the ERK1 and ERK2 pathways. When growth factors bind to the receptor tyrosine kinase, Ras interacts with Raf, the serine/threonine protein kinase and activates it as well. Once actived, Raf phosphorylates serine residue in 2 further kinases, MEK1/2, which in turn phosphorylates tyrosine/threonine in extracellular-signal regulated kinase(ERK) 1/2. Upon activation, the ERKs either phosphorylate a number of cytoplasmic targets or migrate to the nucleus, where they phosphorylate and activate a number of transcription factors such as c-Fos and Elk-1. Involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK-1. Phosphorylates EIF4EBP1; required for initiation of translation. Phosphorylates microtubule-associated protein 2 (MAP2). Phosphorylates SPZ1. Phosphorylates heat shock factor protein 4 (HSF4).

Alternate Names/Synonyms: ERT2; ERK1; ERK-1; MAPK3; MAPK 3; p44-ERK1; p44-MAPK; EC=2.7.11.24; MAP Kinase 3; MAP Kinase Isoform p44; Insulin-stimulated MAP2 Kinase; Mitogen-activated Protein Kinase 3; ERT1; ERK2; MAPK1; ERK-2; MAPK 2; MAPK 1; p42-MAPK; MAP Kinase 1; MAP Kinase 2; M

Product Type: Monoclonal Antibody

Clone: 9B3

Isotype: Mouse IgG2b kappa

Immunogen: Synthetic peptide (KLH coupled) corresponding to residues around Thr202/Tyr204 of human p44 MAP kinase (Erk1).

Applications: WB

Species Crossreactivity: Human, Mouse, Rat

Formulation: Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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Literature References: 1) Smalley, K. (2003) Int. J. Cancer, 104, 527-532. (General)2) Johnson, G.L. and Lapadat, R. (2002) Science, 298, 1911-1912. (General)3) Kolch, W. (2000) Biochem. J. 351, 289-305. (General)