anti-Fibrinogen, mAb (5C5)

Product description: Monoclonal Antibody. Recognizes the Human protein. Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. Fibrinogen is a soluble glycoprotein found in the plasma, with a molecular weight of 340kDa. It comprises of three pairs of non-identical polypeptide chains (alpha, 63.5kDa beta, 56kDa, and gamma, 47kDa chains) linked to each other by disulphide bonds. Low plasma fibrinogen concentrations are therefore associated with an increased risk of bleeding due to impaired primary and secondary hemostasis. Therefore Fibrinogen is an essential component of the blood coagulation system. Also it may play key roles in the process of atherosclerotic lesion formation, with subsequent effects on cardiovascular diseases. And increasing evidence from epidemiological studies suggests that elevated plasma fibrinogen levels are associated with an increased risk of ischaemic heart disease(IHD), stroke and other thromboembolism. Fibrinogen has a double function, yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation.

Alternate Names/Synonyms: FGA; FGB; FGG

Product Type: Monoclonal Antibody

Clone: 5C5

Isotype: Mouse IgG1 kappa

Immunogen: Fibrinogen protein purified from human plasma.

Applications: ELISA, IHC, WB

Species Crossreactivity: Human

Formulation: Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

Lien vers la Fiche Technique

Literature References: 1) S. Kamath et al. (2003) Fibrinogen: Biochemistry, epidemiology and determinants. Q J Med 96:711-729. (General)