anti-Fibronectin, mAb (23C9)

Product description: Monoclonal Antibody. Recognizes the Human protein. Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. Fibronectin (FN) exists in two main forms: 1) as a soluble glycoprotein in blood plasma (plasma FN), and 2) as an insoluble glycoprotein in tissue extracellular matrices (cellular FN). Many different cell types synthesize fibronectin and secrete it as a disulfide-bonded dimer composed of 230°270 kDa subunits. FN is one of the largest multi-domain proteins that interact with a variety of macromolecules like heparin, collagen /gelatin, and fibrin. FN is involved in many cellular processes, including tissue repair, embryogenesis, blood clotting, and cell migration/ adhesion and so can be used as a therapeutic agent for wound healing. In addition, its age-dependent increase in plasma and tissues may be accompanied in pathological states, especially in tumor growth, by its proteolytic breakdown. Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Anastellin binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling.

Alternate Names/Synonyms: FN; FN1

Product Type: Monoclonal Antibody

Clone: 23C9

Isotype: Mouse IgG2b kappa

Immunogen: Fibronectin protein purified from human plasma.

Applications: IP, WB

Species Crossreactivity: Human

Formulation: Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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Literature References: 1) Mao, Y. and Schwarzbauer, J. E. (2005) Matrix Biology 24(6) 389-399. (General)2) Carsons, S. E. (1989). Fibronectin in Health and Disease. Florida: CRC Press, Inc. (General)