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5 mg

Ref. BVT-0424-M005

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Neuf 280.00 H.T.


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Détails Produit

Product description: Chemical. CAS: 23110-15-8. Formula: C26H34O7. MW: 458.6. Isolated from Aspergillus fumigatus (Strain WDMH-35). Meroterpenoid antibiotic. Anticancer, antimicrobial, antimalarial and amoebicidal compound. Potent, selective and covalent inhibitor of methionine aminopeptidase-2 (MetAP2). Anti-angiogenic by impairing the growth of endothelial cells and altering gene expression. Inhibits endothelial cell proliferation in vitro and tumor-induced angiogenesis in vivo. Suppresses the HIV-1 infection of human macrophages through the inhibition of HIV-1 viral protein R (Vpr) activity. Inhibits neovascularization and might be useful in non-tumor diseases such as diabetic retinopathy, arthritis and psoriasis, which involve neovascularisation processes. Reduces diet-induced adipose tissue formation in mice, independent of its effects on angiogenesis.

Alternate Names/Synonyms: Amebacilin; Fugilin; Fumidil; Fumadil B; NSC9168; U5762

Product Type: Chemical

Molecular Formula: C26H34O7

Molecular Weight: 458.6

CAS: 23110-15-8

Source / Host: Isolated from Aspergillus fumigatus (Strain WDMH-35).

Purity: >98% (NMR)


Appearance: Off-white solid.

Solubility: Soluble in DMSO, acetone or chloroform. Slightly soluble in methanol or ethanol. Insoluble in water.

Short Term Storage: +4°C

Long Term Storage: -20°C

Long Shipping: AMBIENT

Use & Stability: Stable for at least 2 years after receipt when stored at -20°C. Store solutions at -20°C in the dark.

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