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AVANTI POLAR LIPIDS , CYGNUS , LARODAN , ADIPOGEN , MYBIOSOURCE , SERVA NORDMARK, BIOWORLD, EDGEBIO , PANREAC APPLICHEM
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Product description: Glutathione reductase (GR) is a member of pyridine nucleotide-disulfide oxidoreductases, which includes the closely related enzymes thioredoxin reductase, lipoamide dehydrogenase, trypanothione reductase and mercuric ion reductase. GR is a cytoplasmic flavoenzyme widely distributed in aerobic organisms. The dimeric protein is composed of two identical subunits, each containing 1 FAD and 1 redox-active disulfide/dithiol as components of the catalytic apparatus. It plays a role in maintaining glutathione (GSH) in its reduced form by catalyzing the reduction of glutathione disulfide (GSSG) (1): GSSG + NADPH + H+ ? 2GSH + NADP+ In most eukaryotic cells, GR maintains the ratio of/[GSSG] elevated, and participates in several vital functions such as the detoxification of reactive oxygen species as well as protein and DNA biosynthesis (2).
Alternate Names/Synonyms: GR; GSR; GLUR; GRase; EC=1.8.1.7; Glutathione Reductase, Mitochondrial
Product Type: Kit
Crossreactivity: Human
Sensitivity: 24.353 pg/ml
Range: 0.03125 ng/ml - 2 ng/ml
Sample Type: Human Serum, Plasma, Cell Lysate, Culture Supernates, Buffered Solution
Assay Type: Sandwich
Detection Type: Colorimetric
Short Term Storage: +4°C
Long Term Storage: +4°C
Shipping: BLUE ICE
Handling Advice Any unused reconstituted standard should be discarded or frozen at -80°C. Standard can be frozen and thawed one time only without loss of immunoreactivity.
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