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0.5 mg

Ref. YIF-LF-P0024
AB FRONTIER

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Neuf 377.00 H.T.

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Détails Produit

Product Description: Glutathione reductase (GR) is a member of pyridine nucleotide-disulfide oxidoreductases, which includes the closely related enzymes thioredoxin reductase, lipoamide dehydrogenase, trypanothione reductase and mercuric ion reductase. GR is a cytoplasmic flavoenzyme widely distributed in aerobic organisms. The dimeric protein is composed of two identical subunits, each containing 1 FAD and 1 redox-active disulfide/dithiol as components of the catalytic apparatus. It plays a role in maintaining glutathione (GSH) in its reduced form by catalyzing the reduction of glutathione disulfide (GSSG) (1): GSSG + NADPH + H+ ? 2GSH + NADP+ In most eukaryotic cells, GR maintains the ratio of/[GSSG] elevated, and participates in several vital functions such as the detoxification of reactive oxygen species as well as protein and DNA biosynthesis (2).

Alternate Names/Synonyms: GR; GSR; GLUR; GRase; EC=1.8.1.7; Glutathione Reductase, Mitochondrial

Product type: Protein

Source / Host: E. coli

Species Crossreactivity: Human

Biological Activity: 19.4U/mg (One unit will reduce 1 µmole of oxidized glutathione per min at pH7.5 at 25°C)

Purity: >95% (SDS-PAGE)

Formulation: Lyophilized from 20mM HEPES, pH 7.5.

Handling Advice: Avoid freeze/thaw cycles.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: After reconstitution, store at -80°C.

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