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100 µl

Ref. YIF-LF-MA0036
ABFRONTIER

photos non contractuelles

Neuf 321.00 H.T.
en stock

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Détails Produit

Product description: Glutathione reductase (GR) is a member of pyridine nucleotide-disulfide oxidoreductases, which includes the closely related enzymes thioredoxin reductase, lipoamide dehydrogenase, trypanothione reductase and mercuric ion reductase. GR is a cytoplasmic flavoenzyme widely distributed in aerobic organisms. The dimeric protein is composed of two identical subunits, each containing 1 FAD and 1 redox-active disulfide/dithiol as components of the catalytic apparatus. It plays a role in maintaining glutathione (GSH) in its reduced form by catalyzing the reduction of glutathione disulfide (GSSG) (1): GSSG + NADPH + H+ >> 2GSH + NADP+. In most eukaryotic cells, GR maintains the ratio of/[GSSG] elevated, and participates in several vital functions such as the detoxification of reactive oxygen species as well as protein and DNA biosynthesis (2). Maintains high levels of reduced glutathione in the cytosol.

Alternate Names/Synonyms: GR; GSR; GLUR; GRase; EC=1.8.1.7; Glutathione Reductase, Mitochondrial

Product Type: Monoclonal Antibody

Clone: 1A7

Isotype: Mouse IgG2a kappa

Immunogen: Recombinant human protein purified from E. coli.

Applications: ELISA, IP

Species Crossreactivity: Human

Formulation: Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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Literature References: 1) Carlberg, I. and Mannervik, B. (1985) J. Biol. Chem. 261: 1629-1635. (General)2) Picaud, T. and Desbois, A. (2002) J. Biol. Chem. 277: 31715-31721. (General)