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100 µl

Ref. YIF-LF-MA0156
AB FRONTIER

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Neuf 331.00 H.T.

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Détails Produit

Product description: Monoclonal Antibody. Recognizes the Human protein. Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. GPI-PLD (glycosylphosphati- dylinositol-specific phospholipase D), a 815-amino acid protein, is expressed in numerous tissues and cells and specifically cleaves GPI-anchored proteins. Liver has the highest level of GPI-PLD expression and is the primary organ contributing to GPI-PLD in the serum. GPI-PLD is abundant in serum in which it associates with apolipoproteins AI and AIV. Increased serum GPI-PLD is associated with insulin resistance and elevated serum triglycerides. Many surface proteins are attached to eukaryotic cell membranes via glycosylphosphatidylinositol (GPI) anchors that are covalently bound to the C-terminus of the protein and cleavage of the GPI moiety by GPI-PLD, only enzyme known that cleavage GPI anchor, may represent a means of regulating attachment of these proteins to the cell surface, or alternatively, their release into the extracellular environment. This protein hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans (GPI-anchor) thus releasing these proteins from the membrane.

Alternate Names/Synonyms: GPLD1; GPI-PLD; PIGPLD1; PI-G PLD; EC=3.1.4.50; Glycoprotein Phospholipase D; GPI-specific Phospholipase D; Phosphatidylinositol-Glycan-Specific Phospholipase D

Product Type: Monoclonal Antibody

Clone: 38A1

Isotype: Mouse IgG1 kappa

Immunogen: Protein purified from human plasma.

Applications: ELISA, IHC, WB

Species Crossreactivity: Human

Formulation: Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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Literature References: 1) Chalasani N et al, J Clin Endocrinol Metab. (2006) vol.91(6): pp.2279-85. (General)2) MANN KJ et al, Biochem. J. (2004) vol.378: pp.641-8. (General)3) Gregory P et al, Bone. (2005) vol.37(2): pp.139-47. (General)4) Raikwar NS et al, Am J Physiol Endocrinol Metab. (2006) vol.290(3): pp.E463-70. (General)