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100 µl

Ref. YIF-LF-MA0315
AB FRONTIER

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Neuf 331.00 H.T.

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Détails Produit

Product description: Monoclonal Antibody. Recognizes the Human, Mouse, Rat protein. Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. Glycogen synthase kinase-3beta (GSK-3beta) is a cytoplasmic serine/threonine protein kinase, which was initially identified as the kinase that phosphorylates glycogen synthase to inhibit glycogen synthesis. GSK3 beta is a ubiquitously expressed kinase that regulates a wide variety of cellular functions including metabolism, gene expression and cytoskeletal integrity. Akt/PI3K reduces GSK-3beta activity by phosphorylation of its Ser9 residue. GSK-3 beta has a critical role in the regulation of the amount of cyclin D1, as this kinase is involved in both cyclin D1 mRNA transcription and ubiquitin-dependent proteolysis. Participates in the Wnt signaling pathway. Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates MUC1 in breast cancer cells, and decreases the interaction of MUC1 with CTNNB1/beta-catenin. Phosphorylates CTNNB1/beta-catenin.

Alternate Names/Synonyms: GSK3B; GSK-3 beta; EC=2.7.11.1; EC=2.7.11.26; Glycogen Synthase Kinase-3 beta; Serine/Threonine-Protein Kinase GSK3B

Product Type: Monoclonal Antibody

Clone: AF12E8

Isotype: Mouse IgG1 kappa

Immunogen: Recombinant human His-GSK3B protein purified from E. coli.

Applications: ELISA, WB

Species Crossreactivity: Human, Mouse, Rat

Formulation: Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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Literature References: 1) Blankesteijn WM et al. (2008) Trends Pharmacol Sci 29(4):175-80. (General)2) Sugden PH et al. (2008) Br J Pharmacol 153 Suppl 1:S137-53. (General)3) Takahashi-Yanaga F and Sasaguri T, (2008) Cell Signal 20(4):581-9. (General)