anti-Hairy and Enhancer of Split 1 (HES), mAb (7H11)

Product description: Monoclonal Antibody. Recognizes the Human, Mouse, Rat protein. Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. The Notch signaling pathway is important for cell-cell communication, which involve gene regulation mechanisms that control multiple cell differentiation processes during embryonic and adult life. It critically influences cell proliferation, differentiation, and apoptosis in metazoans. The hairy and enhancer of split (HES) family is a basic helix-loop-helix (bHLH) type trancriptional repressor and acts as Notch effectors by negatively regulating expression of downstream target genes such as tissue-specific transcription factors. HES-1 is an upstream negative regulator of REST expression. Silencing of the transcriptional repressor REST is required for terminal differentiation of neuronal and beta-cells. Recent integrative genomic analyses on HES/HEY family suggest that HES1 and HES3 are target genes of the embryonic stem cell-specific network of transcription factors, and that HES1, HES5, HEY1, HEY2 and HEYL are target genes of Notch signaling pathway.

Alternate Names/Synonyms: hHL; HES1; BHLHB39; bHLHb39; Hairy Homolog; Hairy-like Protein; Transcription Factor HES-1; Hairy and Enhancer of Split 1; Class B Basic Helix-Loop-Helix Protein 39

Product Type: Monoclonal Antibody

Clone: 7H11

Isotype: Mouse IgG2b kappa

Immunogen: Recombinant human His-Hes1 protein purified from E. coli.

Applications: ELISA, IP, WB

Species Crossreactivity: Human, Mouse, Rat

Formulation: Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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Literature References: 1) Kato, M. and Kato, M. (2007) Int J Oncol. 31:461-466. (General)2) Abderrahmani, A. et al. (2005) FEBS Lett. 579:6199-6204. (General)3) Iso, T. et al. (2003) J Cell Physiol. 194:237-255. (General)