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100 µl

Ref. YIF-LF-MA0277
AB FRONTIER

photos non contractuelles

Neuf 331.00 H.T.

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Détails Produit

Product description: Monoclonal Antibody. Recognizes the Human protein. Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. Hemoglobin (haemoglobin, Hb) is the iron-containing oxygen-transport protein in the red blood cells of vertebrates. Its chief physiological function is to transport oxygen from the lungs or gills to the tissues where it releases the oxygen for the cellular respiration. Hb A (most of adult hemoglobin) is a tetrameric protein with a molecular weight of 64,500 Da, consisting of two identical alpha-chains of 141 amino acids each, and two identical beta-chains of 146 amino acids each. Each subunit or chain of Hb A adopts a three dimensional structure, called the globin fold, similar to that of the related, monomeric protein myoglobin (Mb). This fold is an arrangement of the helices which forms a pocket that encloses and binds a heme prosthetic group which consists of an iron (Fe) ion held in a heterocyclic ring, known as a porphyrin. The binding of oxygen is a cooperative process. The binding affinity of hemoglobin for oxygen is increased by the oxygen saturation of the molecule. the oxygen binding curve of hemoglobin is sigmoidal, or S-shaped, as opposed to the normal hyperbolic curve associated with noncooperative binding. Hemoglobin's oxygen-binding capacity is decreased in the presence of carbon monoxide because both gases compete for the same binding sites on hemoglobin. Carbon dioxide occupies a different binding site on the hemoglobin. Some mutations in the globin chain are associated with the hemoglobinopathies, such as sickle-cell disease and thalassemia. Hemoglobin (Hb)-based O2 carriers (HBOCs) such as hemoglobin vesicle (HbV) have been investigated as a transfusion alternative and other clinical applications. Involved in oxygen transport from the lung to the various peripheral tissues. LVV-hemorphin-7 potentiates the activity of bradykinin, causing a decrease in blood pressure.

Alternate Names/Synonyms: HBB

Product Type: Monoclonal Antibody

Clone: 7E1F

Isotype: Mouse IgG1 kappa

Immunogen: Human plasma.

Applications: ELISA, WB

Species Crossreactivity: Human

Formulation: Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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Literature References: 1) Sakai H et al. (2008) J Intern Med. 263(1):4-15. (General)2) Lukin JA and Ho C, (2004) Chem Rev. 104(3):1219-1230. (General)