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Product description: Hematopoietic tyrosine phosphatase (HePTP, PTPN7) belongs to a subgroup of PTPases with two other members, STEP and PCPTP1. HePTP is a 38 kDa class I non-receptor protein tyrosine phosphatase (PTP) that is strongly expressed in T cells. The protein consists of a short, amino-terminal extension that contains a conserved 16-amino acid kinase interaction motif (KIM) and a carboxy-terminal protein tyrosine phosphatase domain. HePTP binds the MAPK family kinases, Erk1/2 and p38 via KIM. Erk phosphorylates HePTP (at Thr45 and Ser72) and HePTP dephosphorylates Erk (at Tyr185). HePTP is phosphorylated at Ser23 within the KIM by PKA in T cells. This phosphorylation results in dissociation of the HePTP/ERK2 complex and reduced ability of HePTP to dephosphorylate ERK. Protein phosphatase that acts preferentially on tyrosine-phosphorylated MAPK1. Plays a role in the regulation of T and B-lymphocyte development and signal transduction.
Alternate Names/Synonyms: HEPTP; PTPN7; EC=3.1.3.48; Protein-Tyrosine Phosphatase LC-PTP; Hematopoietic Protein-Tyrosine Phosphatase; Tyrosine-Protein Phosphatase Non-Receptor Type 7
Product Type: Monoclonal Antibody
Clone: AFPK32
Isotype: Mouse IgG1 kappa
Immunogen: Recombinant human protein purified from E. coli.
Applications: ELISA, WB
Species Crossreactivity: Human
Formulation: Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Long Term Storage: -20°C
Shipping: BLUE ICE
Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.
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