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100 µl

Ref. YIF-LF-MA0211
AB Frontier

photos non contractuelles

Neuf 309.00 H.T.


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Détails Produit

Product description: Hematopoietic progenitor kinase 1 (HPK1) is a 97 kDa serine/threonine protein kinase expressed only in hematopoietic cells and tissues. HPK1 is comprosed of a STE20-like kinase domain in its N-terminus, four proline-rich motifs (-P-x-x-P-), a caspase cleavage site, and a distal C-terminal Citron homology domain. The proline-rich motifs are capable of binding proteins that contain SH3 domains. HPK1 is involved in many cellular signaling cascades that include MAPK signaling, antigen receptor signaling, apoptosis, growth factor signaling, and cytokine signaling. HPK1 binds many adaptor proteins including members of the Grb2 family, Nck family, Crk family, SLP-76 family, and actin-binding adaptors. HPK1 contains 13 potential tyrosine phosphorylation residues, some of which may be phosphorylated by ZAP-70, which provide potential docking sites for SH2 domains containing proteins. HPK1 is activated by both EGF and PDGF stimulation where adaptor proteins are involved in mediating the localization of effector molecules to cell surface receptors. Activation-induced cell death (AICD)-resistant T cells contain full-length HPK1, while AICD-sensitive T cells have HPK1-C (cleaved form). HPK1 might be a possible molecular switch used to discriminate between the extrinsic pathway involving death receptors and the intrinsic pathway determined by the ratio between anti- and pro-apoptotic Bcl-2 family members. May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in hematopoietic lineage decisions and growth regulation.

Alternate Names/Synonyms: HPK1; MAP4K1; MEKKK 1; EC=; MEK Kinase Kinase 1; MAPK/ERK Kinase Kinase Kinase 1; Hematopoietic Progenitor Kinase; Mitogen-activated Protein Kinase Kinase Kinase Kinase 1

Product Type: Monoclonal Antibody

Clone: 2A1

Isotype: Mouse IgG1 lambda

Immunogen: Recombinant human His/ABD-HPK1 protein purified from E. coli.

Applications: IP, WB

Species Crossreactivity: Human

Formulation: Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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