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Product description: Monoclonal Antibody. Recognizes the Human protein. Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. The Heat shock protein 70 (HSP70) family was found in many intracellular compartments. Members of this protein occur in chloroplasts, endoplasmic reticulum, mitochondria, and cytosol. These proteins are induced by a variety of biological stresses, including heat stress, in every organism. HSP70 serves a variety of roles: 1) It acts as molecular chaperones facilitating the assembly of multi-protein complexes, 2) It participates in the translocation of polypeptides across cell membranes and to the nucleus 3) It aids in the proper folding of nascent polypeptide chains. HSP70 is mitochondrial import machinery and plays key roles in the cytosolic endoplasmic reticulum. Recently, extracellular localized HSP have been found to play key roles in the induction of a cellular immune response. In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell.
Alternate Names/Synonyms: HSPA1; HSPA1A; HSP70.1/HSP70.2; HSP70-1/HSP70-2; Heat Shock 70 kDa Protein 1/2; Heat Shock 70 kDa Protein 1A/1B
Product Type: Monoclonal Antibody
Isotype: Mouse IgG2b lambda
Immunogen: Recombinant human HSP70 protein purified E. coli.
Applications: ELISA, IHC, IP, WB
Species Crossreactivity: Human
Formulation: Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Short Term Storage: +4°C
Long Term Storage: -20°C
Shipping: BLUE ICE
Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.
Literature References: 1) Multhoff G, et al. (2002) Int J Hyperthermia. 18(6):576-85. (General)2) Martin J, et al.(1992) Science 258(5084):995-8. (General)3) Hatayama T, et al.(1992) J Biochem 111(4):484-90. (General)4) Haas IG. (1995) FEBS Lett. (1995) 369(1):72-5. (General)
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