anti-IgA (human) (47C12)

Product description: Monoclonal Antibody. Recognizes the Human protein. Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. IgA represents about 15% to 20% of immunoglobulins in the blood, although it is primarily secreted across the mucosal tract into the stomach and intestines. This prevents microbes from binding to epithelial cells in the digestive and respiratory tracts. It does not activate complement, and opsonises only weakly. It exists in two forms, IgA1 (90%) and IgA2 (10%) that differ in the structure. IgA1 is composed like other proteins, however in IgA2 the heavy and light chains are not linked with disulfide but with noncovalent bonds. IgA1 is found in serum and made by bone marrow B cells, however IgA2 is made by B cells located in the mucosae and has been found to secrete into, colostrum, maternal milk, tears and saliva. The IgA found in secretions represent dimeric form, linked by two additional chains, the J chain and the secretory chain. Decreased or absent IgA, termed selective IgA deficiency, can be a clinically significant immunodeficiency. Igalpha is the major immunoglobulin class in body secretions. It may serve both to defend against local infection and to prevent access of foreign antigens to the general immunologic system.

Alternate Names/Synonyms: IGHA2; Ig alpha-2 Chain C Region

Product Type: Monoclonal Antibody

Clone: 47C12

Isotype: Mouse IgG1 kappa

Immunogen: Protein purified from human plasma.

Applications: ELISA, IHC, IP, WB

Species Crossreactivity: Human

Formulation: Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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Literature References: 1) Grubb R. Exp Clin Immunogenet. (1995) vol.12(3): pp.191-7. (General)2) Stewart AK, Schwartz RS. Blood. (1994) vol.83(7): pp.1717-30. (General)