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100 µl

Ref. YIF-LF-MA0148
AB FRONTIER

photos non contractuelles

Neuf 331.00 H.T.

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Détails Produit

Product description: Monoclonal Antibody. Recognizes the Human protein. Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. The inter-alpha-trypsin inhibitor (ITI, IalphaI) family, a typical and classical example for protein-glycosaminoglycan-protein (PGP) complexes, occurs constitutively in plasma at relatively high concentrations and is a result of alternate combinations of three kinds of heavy chains with a common light chain, the bikunin proteoglycan. Bikunin has two proteinase inhibitor domains and belongs to the Kunitz-type protease inhibitor family; it displays an inhibitory activity against trypsin, leukocyte elastase and plasmin. The heavy chains do not have any protease inhibitory properties but have the capacity to interact in vitro and in vivo with hyaluronic acid and this binding promotes the stability of the extra-cellular matrix. The ITI protein family is suspected of playing a key role in the extra-cellular matrix biology. May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes. Contains a potential peptide which could stimulate a broad spectrum of phagocytotic cells.

Alternate Names/Synonyms: SHAP; ITIH1; IGHEP1; ITI-HC1; ITI Heavy Chain H1; Inter-alpha-Inhibitor Heavy Chain 1; Serum-derived Hyaluronan-associated Protein; Inter-alpha-Trypsin Inhibitor Heavy Chain H1

Product Type: Monoclonal Antibody

Clone: 40B10

Isotype: Mouse IgG1 kappa

Immunogen: Protein purified from human plasma.

Applications: IHC, WB

Species Crossreactivity: Human

Formulation: Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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Literature References: 1) Cuvelier A. et al, Rev Mal Respir. (2000) vol.17(2): pp.437~446. (General)2) Zhuo L. et al, J. Biol. Chem. (2004) vol.279(37): pp.38079~38082. (General)3) Tamra, E. et al, Cancer Res. (2006) vol.66(3): pp.1464~1472. (General)4) Salier J.P. et al, Biochem J. (1996) vol.315 (Pt 1) : pp.1~9. (General)