anti-IRS2, mAb (AF2F2)

Product description: Monoclonal Antibody. Recognizes the Human protein. Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. Insulin receptor substrate (IRS) proteins play a central role in maintaining basic cellular functions such as growth and metabolism through insulin/insulin like growth factor (IGF) signaling. Four members (IRS-1, IRS-2, IRS-3, IRS-4) of this family have been identified which differ in their subcellular distribution and interaction with SH2 domain proteins. After phosphorylation by activated receptors, these intracellular signaling molecules recruit various downstream effector pathways including phosphatidylinositol 3-kinase, tyrosine protein phosphatase SHPTP-2, and several smaller adapter molecules such as the growth factor receptor-binding protein Grb-2. IRSs are also thought to be able to induce malignant transformation. May mediate the control of various cellular processes by insulin.

Alternate Names/Synonyms: IRS2; IRS-2; Insulin Receptor Substrate 2

Product Type: Monoclonal Antibody

Clone: AF2F2

Isotype: Mouse IgG1 kappa

Immunogen: Recombinant human His-IRS2 protein purified from E. coli.

Applications: ELISA, WB

Species Crossreactivity: Human

Formulation: Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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Literature References: 1) Dearth R.K. et al. (2007) Cell Cycle. 6:705-713. (General)2) White M.F. (2002) Am J Physiol Endocrinol Metab. 283:E413-E422. (General)3) Burks D.J. and White M.F. (2001) Diabetes 50:S140-S145. (General)4) Giovannone B. et al. (2000) Diabetes Metab Res Rev. 16:434-441. (General)