anti-ITI H4, mAb (45A12)

Product description: Monoclonal Antibody. Recognizes the Human protein. Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. The inter-alpha-trypsin inhibitor (ITI, IalphaI) family, a typical and classical example for protein-glycosaminoglycanprotein (PGP) complexes, occurs constitutively in plasma at relatively high concentrations and is a result of alternate combinations of three kinds of heavy chains with a common light chain, the bikunin proteoglycan. Bikunin has two proteinase inhibitor domains and belongs to the Kunitz-type protease inhibitor family, it displays an inhibitory activity against trypsin, leukocyte elastase and plasmin. The heavy chains do not have any protease inhibitory properties but have the capacity to interact in vitro and in vivo with hyaluronic acid and this binding promotes the stability of the extra-cellular matrix. The ITI protein family is suspected of playing a key role in the extra-cellular matrix biology. May be involved in acute phase reactions.

Alternate Names/Synonyms: IHRP; ITIH4; PRO1851

Product Type: Monoclonal Antibody

Clone: 45A12

Isotype: Mouse IgG1 kappa

Immunogen: Protein purified from human plasma.

Applications: ELISA, IHC, WB

Species Crossreactivity: Human

Formulation: Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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Literature References: 1) Tamra, E. et al. 2006, Cancer Res. 66:1464-1472. (General)2) Zhuo, L. et al. 2004, J. Biol. Chem. 279:38079-38082. (General)3) Cuvelier, A. et al. 2000, Rev Mal Respir. 17:437-446. (General)4) Salier, J.P. et al. 1996, Biochem J. 315(Pt 1) :1-9. (General)