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100 µl

Ref. YIF-LF-MA0109
AB FRONTIER

photos non contractuelles

Neuf 331.00 H.T.

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Détails Produit

Product description: Monoclonal Antibody. Recognizes the Human protein. Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. Lactoferrin (Lf), one of transferrin family, is found in external fluids, including milk and mucosal secretions, and prominent components of the secondary granules of neutrophils. Lf consists of a single polypeptide chain (approximately 80 kDa) folded into two structurally homologous lobes, each of which can reversibly bind one ferric ion (Fe3+). Lf plays a central role in iron metabolism and host defense system against microbial infection. Transferrins are iron binding transport proteins which can bind two Fe3+ ions in association with the binding of an anion, usually bicarbonate. Lactotransferrin has antimicrobial activity which depends on the extracellular cation concentration. Lactoferroxins A, B and C have opioid antagonist activity. Lactoferroxin A shows preference for mu-receptors, while lactoferroxin B and C have somewhat higher degrees of preference for kappa-receptors than for µ-receptors. The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity

Alternate Names/Synonyms: LTF; GIG12; EC=3.4.21.

Product Type: Monoclonal Antibody

Clone: 1B8

Isotype: Mouse IgG1 kappa

Immunogen: Recombinant human protein purified from E. coli.

Applications: IHC, IP

Species Crossreactivity: Human

Formulation: Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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Literature References: 1) Farnaud, S. and Evans, R.W. (2003) Mol. Immunol. 40, 395-405. (General)2) Baker, H.M. et al. (2003) Proc. Natl. Acad. Sci. USA 100, 3579-3583. (General)3) Appelmelk, B.J. et al. (1994) Infect. Immun. 62, 2628-2632. (General)