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100 µl

Ref. YIF-LF-MA0340

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Neuf 331.00 H.T.


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Détails Produit

Product description: Monoclonal Antibody. Recognizes the Human, Mouse, Rat protein. Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. Lactate dehydrogenase (LDH) is the enzyme in the glycolytic pathway that converts pyruvate to lactate with concomitant interconversion of NADH and NAD+. In mammals, the enzyme is encoded by three genes: LDHA (M or muscle form), LDHB (H or heart form), and LDHC (X or testis form). The three human LDHs have 84°89% sequence similarities and 69°75% amino acid identities. There are five different LDH isoenzymes based on the proportion of M and H chains existing in the LDH tetrameric structure. The LDHA is hypoxia inducible and its expression is directly controlled by the transcriptional activity of the hypoxia inducible factor 1alpha (HIF1alpha). LDHB is also known to be upregulated in many cancers.

Alternate Names/Synonyms: LDHA; PIG19; LDH-A; LDH-M; EC=; LDH Muscle Subunit; L-Lactate Dehydrogenase A Chain; Renal Carcinoma Antigen NY-REN-59; Cell Proliferation-inducing Gene 19 Protein

Product Type: Monoclonal Antibody

Clone: AF9D1

Isotype: Mouse IgG1 kappa

Immunogen: Recombinant human His-LDHA protein purified from E. coli.

Applications: ELISA, WB

Species Crossreactivity: Human, Mouse, Rat

Formulation: Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

Lien vers la Fiche Technique

Literature References: 1) Mdluli K et al. (2005) Biochim Biophys Acta 1753(2):209-16. (General)2) Xie H et al, (2009) Mol Cancer Ther 8(3):626-35. (General)3) Giatromanolaki A et al, (2008) Leuk Lymphoma 49(11) :2181-6. (General)