Plus de 40 ans d’expérience à votre service

Tel. : 01 45 33 67 17 / E-mail : coger@coger.fr

Stock épuisé.
En rupture de stock
Quantité minimum d'achat
La quantité minimum d'achat n'est pas atteinte

 

 

100 µl

Ref. YIF-LF-MA0260
AB FRONTIER

photos non contractuelles

Neuf 331.00 H.T.

Quantité

Alerte réapprovisionnement
Recevez une alerte par email dès que votre choix sera de retour en stock
Votre e-mail*:

Détails Produit

Product description: Monoclonal Antibody. Recognizes the Human, Mouse, Rat protein. Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. Sequential activation of protein kinases within the MAPK (mitogen-activated protein kinases) cascades is a common mechanism of signal transduction in many cellular processes. The ERK signaling cascade is a central MAPK pathway that plays a role in the regulation of various cellular processes such as proliferation, differentiation, development, learning, and survival. Mitogen-activated protein kinase kinases (MAPKK) phosphorylate MAPK. MEK (MAP kinase or ERK kinase) is the immediate upstream activator kinase of ERK. The human MEK3 encodes 347 amino acid residues. MEKs (MEK1, MEK2, MEK3) show remarkably different activity toward ERKl and ERK2. MEK2 is the most active ERK activator. MEK3 is inactive toward ERKl or ERK2. MEK3, MEK4, and MEK6 phosphorylate and activate p38 MAP kinase. The p38 mitogen-activated protein (MAP) kinase signal transduction pathway is activated by proinflammatory cytokines and environmental stress. Transcription factors such as ATF2 and Elk-1 are targets of the p38 MAP kinase signal transduction pathway. Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38.

Alternate Names/Synonyms: MEK3; MEK 3; MAP2K3; SAPKK2; SAPKK-2; MAPKK 3; EC=2.7.12.2; SAPK Kinase 2; MAPK/ERK Kinase 3; MAP Kinase Kinase 3; Stress-activated Protein Kinase Kinase 2

Product Type: Monoclonal Antibody

Clone: 3G2

Isotype: Mouse IgG2a kappa

Immunogen: Recombinant human His-MEK3 protein purified from E. coli.

Applications: WB

Species Crossreactivity: Human, Mouse, Rat

Formulation: Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

Lien vers la Fiche Technique

Literature References: 1) Shaul YD and Seger R, (2007) Biochim Biophys Acta. 1773(8):1213-1226. (General)2) Raingeaud J et al. (1996) Mol Cell Biol. 16(3):1247-1255. (General)3) Zheng CF and Guan KL, (1993) J. Biol. Chem. 268:11435-11439. (General)